MersV1, Main, Exploration, bibRecord, 004940

Drug-oligonucleotide conjugates

Identifieur interne : 004940 ( Main/Exploration ); précédent : 004939; suivant : 004941

Drug-oligonucleotide conjugates

Auteurs : S. R. Byrn [États-Unis] ; D. V. Carlson [États-Unis] ; J. K. Chen [États-Unis] ; M. S. Cushman [États-Unis] ; M. E. Goldman [États-Unis] ; W. P. Ma [États-Unis] ; C. L. Pidgeon [États-Unis] ; K. A. Ray [États-Unis] ; J. G. Stowell [États-Unis] ; H. L. Weith [États-Unis]

Source :

Advanced Drug Delivery Reviews [ 0169-409X ] ; 1991.

RBID : ISTEX:E354E648F286F256D23033687CB9417C9399905E

English descriptors

Teeft :
- Acad, Acridine, Acridines, Agrawal, Alkaloid, Antisense, Antisense conjugates, Antisense oligonucleotide, Antisense oligonucleotides, Antiviral activity, Assay, Asseline, Benzophenanthridine, Benzophenanthridine alkaloids, Biochem, Biochemistry, Biol, Biological activity, Biological effects, Byrn, Cazenave, Chem, Cholesterol conjugates, Coli, Coli rnase, Conjugate, Dervan, Duplex, Fagaronine, Fagaronine chloride, Febs lett, Goodchild, Hand side, Intercalating agents, Intercalator, Letsinger, Linker, Linker arms, Liposome, Natl, Nuclease digestion, Nucleic, Nucleic acids, Numerous studies, Oligonucleotide, Oligonucleotide conjugate, Oligonucleotides, Phosphoramidite, Proc, Right hand side, Rnase, Sarin, Thuong, Toulm6, Transcriptase, Transcriptase assay, Triple strand formation, Viral rnase, Wide range, Zamecnik.

Abstract

Abstract: In this review, drug oligonucleotide conjugates synthesized and characterized in our laboratories will be discussed. An idealized view of a complex between an acridine-oligonucleotide conjugate and RNA is shown above. In addition, other related conjugates will be reviewed. The goal of this review is to establish that it is now feasible to synthesize a wide range of drug oligonucleotide conjugates. The testing of these molecules will provide important information on the pharmacological usefulness of targeting drugs to specific sequences using oligonucleotides.

Url:

https://api.istex.fr/ark:/67375/6H6-SC92MST1-G/fulltext.pdf

DOI: 10.1016/0169-409X(91)90022-5

Affiliations:

États-Unis

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Le document en format XML

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<term>Acridine</term>
<term>Acridines</term>
<term>Agrawal</term>
<term>Alkaloid</term>
<term>Antisense</term>
<term>Antisense conjugates</term>
<term>Antisense oligonucleotide</term>
<term>Antisense oligonucleotides</term>
<term>Antiviral activity</term>
<term>Assay</term>
<term>Asseline</term>
<term>Benzophenanthridine</term>
<term>Benzophenanthridine alkaloids</term>
<term>Biochem</term>
<term>Biochemistry</term>
<term>Biol</term>
<term>Biological activity</term>
<term>Biological effects</term>
<term>Byrn</term>
<term>Cazenave</term>
<term>Chem</term>
<term>Cholesterol conjugates</term>
<term>Coli</term>
<term>Coli rnase</term>
<term>Conjugate</term>
<term>Dervan</term>
<term>Duplex</term>
<term>Fagaronine</term>
<term>Fagaronine chloride</term>
<term>Febs lett</term>
<term>Goodchild</term>
<term>Hand side</term>
<term>Intercalating agents</term>
<term>Intercalator</term>
<term>Letsinger</term>
<term>Linker</term>
<term>Linker arms</term>
<term>Liposome</term>
<term>Natl</term>
<term>Nuclease digestion</term>
<term>Nucleic</term>
<term>Nucleic acids</term>
<term>Numerous studies</term>
<term>Oligonucleotide</term>
<term>Oligonucleotide conjugate</term>
<term>Oligonucleotides</term>
<term>Phosphoramidite</term>
<term>Proc</term>
<term>Right hand side</term>
<term>Rnase</term>
<term>Sarin</term>
<term>Thuong</term>
<term>Toulm6</term>
<term>Transcriptase</term>
<term>Transcriptase assay</term>
<term>Triple strand formation</term>
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<front><div type="abstract" xml:lang="en">Abstract: In this review, drug oligonucleotide conjugates synthesized and characterized in our laboratories will be discussed. An idealized view of a complex between an acridine-oligonucleotide conjugate and RNA is shown above. In addition, other related conjugates will be reviewed. The goal of this review is to establish that it is now feasible to synthesize a wide range of drug oligonucleotide conjugates. The testing of these molecules will provide important information on the pharmacological usefulness of targeting drugs to specific sequences using oligonucleotides.</div>
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Drug-oligonucleotide conjugates

Drug-oligonucleotide conjugates

Source :

English descriptors

Abstract

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